Nicole Kidman and Liane Moriarty have been partners since 2016, when Kidman's Blossom Films teamed up with Reese Witherspoon's Hello Sunshine to produce an adaptation of Moriarty's best-selling Big Little Lies for HBO. Kidman and Witherspoon's push to create TV series that star women over 40 with juicy roles for themselves was a radical move in Hollywood, helping to change the entertainment landscape. Witherspoon had a few not-nearly as successful series before Witherspoon sold it off, but Kidman has stayed steadfast with Blossom, adapting Moriaty's The Last Anniversary and Nine Perfect Strangers, the latter of which will debut Season 2 on Hulu in May.

Kidman has stated in interviews that her goal in continuing with Blossom is to create enough projects to be able to hire as many older actors as she can, stepping aside and staying behind the camera (as she did with The Last Anniversary) so others can have a go. However, for Nine Perfect Strangers, she took the juiciest role for herself: guru Masha Dmitrichenko. Season 1 had her as the head of Tranquillum House, where she gathered nine people to attend her wellness retreat, with a determination to give them emotional breakthroughs, whether they wanted one or not.

Season 1 also was primarily an American and Australian cast, most of whose stories were close-ended. So when the series was commissioned for Season 2, Kidman decided not to attempt to continue their stories. Instead, she and Moriarty created an anthology series, developing a new story, a new wellness retreat, nine new clients, and Masha going full ice queen in the Australian Alps.